Dopamine D1-like, D2 and D3 Receptor Subtypes in Catalepsy Sensitization and Conditioning in Rats: Implications for Motor Function, Motivation and Learning

........................................................................................................................................... ii Co-Authorship................................................................................................................................. iv List of Figures ................................................................................................................................. ix List of Abbreviations...........................................................................................x Chapter 1 General Introduction........................................................................................................ 1 1.1 Dopamine Neuron Anatomy .................................................................................................. 2 1.2 Dopamine Neuron Physiology ............................................................................................... 4 1.3 Dopamine Receptor Subtypes ................................................................................................ 5 1.4 Dopamine and Motor Function .............................................................................................. 7 1.5 Dopamine and Motivation ..................................................................................................... 9 1.6 Dopamine and Stimulus-Reward Learning .......................................................................... 14 1.7 Dopamine and Behavioral Sensitization .............................................................................. 18 1.8 Hypothesis............................................................................................................................ 21 1.9 References ............................................................................................................................ 23 Chapter 2 Haloperidol Conditioned Catalepsy in Rats: A Possible Role for D1-like Receptors ... 37 2.1 Abstract ................................................................................................................................ 38 2.2 Introduction .......................................................................................................................... 39 2.3 Materials and Methods ......................................................................................................... 41 2.3.1 Subjects ......................................................................................................................... 41 2.3.2 Drugs ............................................................................................................................. 41 2.3.3 Behavioral Testing ........................................................................................................ 41 2.3.4 Experimental Design ..................................................................................................... 42 2.3.5 Statistics ........................................................................................................................ 44 2.4 Results .................................................................................................................................. 44 2.4.1 Experiment 1: Haloperidol Catalepsy ........................................................................... 44 2.4.2 Experiment 2: SCH 23390 Catalepsy ........................................................................... 47 2.4.3 Experiment 3: Haloperidol + SCH 23390 Catalepsy .................................................... 47 2.5 Discussion ............................................................................................................................ 48 2.6 References ............................................................................................................................ 59 Chapter 3 Reduced Expression of Haloperidol Conditioned Catalepsy in Rats by the Dopamine D3 Receptor Antagonists Nafadotride and NGB 2904 ........................................................................ 67 3.1 Abstract ................................................................................................................................ 68